Epstein-Barr virus latent membrane protein 1 induces CD69 expression through activation of nuclear factor-κB

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Epstein-Barr virus latent membrane protein 1 induces CD69 expression through activation of nuclear factor-κB.

Latent membrane protein‑1 (LMP-1) of Epstein‑Barr virus (EBV) promotes tumorigenesis. Here, we report that LMP-1 activates the immunoregulatory molecule CD69 gene transcription through a nuclear factor-κB (NF-κB)‑dependent pathway. CD69 expression was upregulated in LMP-1‑expressing EBV-immortalized human B-cell lines and an EBV-positive Burkitt's lymphoma cell line. LMP-1 expression increased ...

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This study shows a mechanism for the increase of signal transducer and activator of transcription 1 (STAT1) in Epstein-Barr virus-immortalized cells. Latent membrane protein 1 (LMP-1) expression was sufficient to induce STAT1 expression, DNA binding, and transcriptional activity. LMP-1-expressing cells can induce an increase in STAT1 expression in LMP-negative cells in the same culture, suggest...

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ژورنال

عنوان ژورنال: International Journal of Oncology

سال: 2013

ISSN: 1019-6439,1791-2423

DOI: 10.3892/ijo.2013.1871